Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
- Authors
- Cruz, Lorena A.; Diaz, Miguel A.; Gupta, Mahabir P.; Lopez-Perez, Jose Luis; Mondolis, Eily; Moran-Pinzon, Juan; Guerrero, Estela
- Format
- Article
- Status
- publishedVersion
- Description
Context: Since there is still a great need to search for plant species with antinociceptive and antiinflammatory activities, Diploptropis purpurea (Rich.) Amshoff (Fabaceae) is studied for the first time. Objective: This evaluates the analgesic and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea (MEDP). Material and methods: The anti-inflammatory and analgesic effects of MEDP of D. purpurea were evaluated in vivo. The antinociceptive activity was assessed in CD1 male mice were treated by oral gavage with 500 mg/kg of MEDP 30 min before submitting to acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Paws oedema induced by carrageenan, histamine or serotonin were performed in male Sprague–Dawley rats to determinate the anti-inflammatory activity. Results: Oral administration of MEDP produced significant antinociceptive effects on the inflammatory phase in the formalin test [12.0 s versus 72.5 s in carboxymethyl cellulose (CMC) control group]. MEDP produced an analgesic effect in the hot-plate model, although the effect was modest compared to tramadol (40 and 60%, respectively). The oral administration of MEDP in a dose of 500 mg/kg showed maximum inhibition (75.1%) after 0.5 h in carrageenan-induced oedema, but it did not modify histamine or serotonin-induced oedemas. Discussion and conclusion: In the peripheral nociception model, acetic acid-induced abdominal writhing, the MEDP did not show a protective effect, but its analgesic effects were evident in the inflammatory phase of the formalin test and in the hot-plate model. These results show that the anti-inflammatory effect was accompanied by a reduction in the perception of painful stimuli.
- Publication Year
- 2019
- Language
- Topic
- QK Botany
R Medicine (General)
RM Therapeutics. Pharmacology
- Repository
- RI Digital de la Universidad de Panamá
- Get full text
- http://up-rid.up.ac.pa/6885/3/lorena_cruz.pdf
- Rights
- openAccess
- License
- cc_by_nc_sa_4